Studies on Insulin Action. 111. Linear Distribtuion of D-glucose, D-ribose and Methanol in Frog Muscle Cells at 0°c in the Absence O F Insulin

In the effective absence of insulin, D-glucose, D-ribose and methanol accumulate inside frog muscle cells at OOC. The steady level distribution coefficients (q), between the cell water and external solution are independent of concentration and are 0.25,0.25 and 0.8 for D-glucose, D-ribose, and methanol, respectively. Preincubation of the muscle with insulin does not change the intracellular concentration of D-ribose or methanol, but adds another fraction of intracellular D-glucose. This additional fraction follows a Langmuir adsorption isotherm.